Which of the following is a typical feature of amyotrophic lateral sclerosis (ALS)?

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that primarily affects motor neurons in the brain and spinal cord, leading to muscle weakness and atrophy. One of the hallmark features of ALS is impaired respiratory function, which occurs due to the weakening of the muscles that control breathing. As the disease progresses, the respiratory muscles become less effective, resulting in difficulties in breathing and a decrease in the individual's ability to perform basic respiratory functions, which can contribute to serious complications and impact overall survival.

Other features associated with ALS include issues with bulbar function, such as difficulty swallowing and speaking, but impaired respiratory function remains a significant concern as the disease advances. The natural progression of muscle weakness in ALS ultimately affects not only voluntary muscles but also involuntary muscles such as those involved in respiration, leading to respiratory failure if not managed appropriately.

Understanding this feature is crucial for recognizing the broader implications of ALS, including the importance of respiratory support and interventions to improve quality of life for affected individuals.