What type of cells secrete pepsinogen in the stomach?

Pepsinogen is an inactive enzyme that is secreted by chief cells, which are specialized cells located in the gastric glands of the stomach lining. When pepsinogen is released into the acidic environment of the stomach, it is converted to its active form, pepsin, by gastric acid (primarily hydrochloric acid secreted by parietal cells).

Chief cells play a crucial role in the digestive process by providing the initial form of the protein-digesting enzyme that will then facilitate protein breakdown when activated. This enzymatic action is fundamental for proper digestion and absorption of nutrients.

Understanding the function and location of chief cells is essential in recognizing how the stomach initiates digestion and the interplay between different types of gastric cells, enhancing comprehension of gastric physiology and pathophysiology.